Reaction Details
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Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Ligand
BDBM203874
Substrate
n/a
Meas. Tech.
TR-FRET Binding A
pH
7.4000±n/a
Temperature
297.1500±n/a K
Ki
104±0 nM
IC50
383±12 nM
Comments
extracted
Citation
Akçay, G; Belmonte, MA; Aquila, B; Chuaqui, C; Hird, AW; Lamb, ML; Rawlins, PB; Su, N; Tentarelli, S; Grimster, NP; Su, Q Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain. Nat Chem Biol 12:931-936 (2016) [PubMed] Article More Info.:
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327]
Synonyms:
Myeloid cell leukemia 1 (Mcl-1) | Induced myeloid leukemia cell differentiation protein Mcl-1(171-327) | MCL1_HUMAN | MCL1 | BCL2L3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17896.13
Organism:
Human
Description:
Q07820[171-327]
Residue:
157
Sequence:
EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGG
Inhibitor
Name:
BDBM203874
Synonyms:
Mcl-1 inhibitor 10
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Cc1c(-c2cccc3c(CCCOc4cccc5ccccc45)c(C(=O)O)[nH]c23)c(COc2ccccc2)nn1C
Structure:
