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Found 278 with Last Name = 'tentarelli' and Initial = 's'
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Oncology Innovative Medicines Unit

LigandPNGBDBM203869(7-(3-((4-Borono-3-formylphenoxy)methyl)-1,5-dimeth...)
Affinity DataKi:  0.900nM ΔG°:  -51.5kJ/mole IC50:  3.40nMpH: 7.4 T: 2°CAssay Description:TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Oncology Innovative Medicines Unit

LigandPNGBDBM203875(7-(3-((4-Borono-3-formylphenoxy)methyl)-1,5-dimeth...)
Affinity DataKi:  1.20nM ΔG°:  -50.7kJ/mole IC50:  4.20nMpH: 7.4 T: 2°CAssay Description:TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Oncology Innovative Medicines Unit

LigandPNGBDBM203870(7-(3-((3-Acetyl-4-boronophenoxy)methyl)-1,5-dimeth...)
Affinity DataKi:  1.20nM ΔG°:  -50.7kJ/mole IC50:  4.70nMpH: 7.4 T: 2°CAssay Description:TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Oncology Innovative Medicines Unit

LigandPNGBDBM203876(Mcl-1 inhibitor 12)
Affinity DataKi:  1.60nM ΔG°:  -50.0kJ/mole IC50:  5.96nMpH: 7.4 T: 2°CAssay Description:TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Oncology Innovative Medicines Unit

LigandPNGBDBM203871(7-(3-((3-formylphenoxy)methyl)-1,5-dimethyl-1H-pyr...)
Affinity DataKi:  16nM ΔG°:  -44.3kJ/mole IC50:  59.5nMpH: 7.4 T: 2°CAssay Description:TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Oncology Innovative Medicines Unit

LigandPNGBDBM203873(7-(3-((4-Boronophenoxy)methyl)-1,5-dimethyl-1H-pyr...)
Affinity DataKi:  44nM ΔG°:  -41.8kJ/mole IC50:  162nMpH: 7.4 T: 2°CAssay Description:TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Oncology Innovative Medicines Unit

LigandPNGBDBM203872(7-(3-((3-Acetylphenoxy)methyl)-1,5-dimethyl-1H-pyr...)
Affinity DataKi:  64nM ΔG°:  -40.9kJ/mole IC50:  237nMpH: 7.4 T: 2°CAssay Description:TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Oncology Innovative Medicines Unit

LigandPNGBDBM203874(Mcl-1 inhibitor 10)
Affinity DataKi:  104nM ΔG°:  -39.7kJ/mole IC50:  383nMpH: 7.4 T: 2°CAssay Description:TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573136(CHEMBL4875486)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50270877((R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex...)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human C-terminal 6xHis-tagged Bcl-2 (M1 to F212 residues) expressed in Escherichia coli using HyLite Fluor 647-labeled BIM ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573135(CHEMBL4873217)
Affinity DataIC50:  2nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573128(CHEMBL4865752)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573130(CHEMBL4855381)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50563643(CHEMBL4754609)
Affinity DataIC50:  5nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581713(CHEMBL5085027)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of PRMT5 in human HCT116-MTAP null cells assessed as reduction in symmetric dimethylation of arginine using SAM as substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581712(CHEMBL5078281)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of PRMT5 in human HCT116-MTAP null cells assessed as reduction in symmetric dimethylation of arginine using SAM as substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM298766(2-amino-5-(1-methyl-1H-pyrazol-4-yl)-N-((1S,2S)-2-...)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50270877((R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex...)
Affinity DataIC50: <8nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged Bcl-xl (1 to 209 residues) expressed in Escherichia coli using HyLite Fluor 647-labeled BIM pep...More data for this Ligand-Target Pair
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581712(CHEMBL5078281)
Affinity DataIC50:  13nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573149(CHEMBL4879167)
Affinity DataIC50:  13nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573127(CHEMBL4849757)
Affinity DataIC50:  13nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573123(CHEMBL4863682)
Affinity DataIC50:  13nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573142(CHEMBL4852375)
Affinity DataIC50:  13nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573129(CHEMBL4872116)
Affinity DataIC50:  16nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573146(CHEMBL4879190)
Affinity DataIC50:  16nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581709(CHEMBL5075691)
Affinity DataIC50:  16nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573120(CHEMBL4869181)
Affinity DataIC50:  16nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581711(CHEMBL5078692)
Affinity DataIC50:  17nMAssay Description:Inhibition of PRMT5 in human HCT116-MTAP null cells assessed as reduction in symmetric dimethylation of arginine using SAM as substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581713(CHEMBL5085027)
Affinity DataIC50:  18nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573144(CHEMBL4846456)
Affinity DataIC50:  20nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581711(CHEMBL5078692)
Affinity DataIC50:  21nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM507762(7-chloro-4-(dimethylamino)-1-phenyl- quinazolin-2(...)
Affinity DataIC50:  22nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573122(CHEMBL4869862)
Affinity DataIC50:  25nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM507762(7-chloro-4-(dimethylamino)-1-phenyl- quinazolin-2(...)
Affinity DataIC50:  25nMAssay Description:Inhibition of PRMT5 in human HCT116-MTAP null cells assessed as reduction in symmetric dimethylation of arginine using SAM as substrate incubated for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50529037(CHEMBL4592905)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged Bcl-xl (1 to 209 residues) expressed in Escherichia coli using HyLite Fluor 647-labeled BIM pep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM298766(2-amino-5-(1-methyl-1H-pyrazol-4-yl)-N-((1S,2S)-2-...)
Affinity DataIC50:  32nMAssay Description:Inhibition of FLAG-tagged AXL (unknown origin) transfected in Cos-7 cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573147(CHEMBL4873714)
Affinity DataIC50:  32nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573130(CHEMBL4855381)
Affinity DataIC50:  32nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573141(CHEMBL4853066)
Affinity DataIC50:  32nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573125(CHEMBL4866573)
Affinity DataIC50:  32nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573137(CHEMBL4870528)
Affinity DataIC50:  32nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573140(CHEMBL4862672)
Affinity DataIC50:  32nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573121(CHEMBL4859554)
Affinity DataIC50:  32nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573136(CHEMBL4875486)
Affinity DataIC50:  40nMAssay Description:Inhibition of AXL (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573139(CHEMBL4856195)
Affinity DataIC50:  40nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573134(CHEMBL4852533)
Affinity DataIC50:  40nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573136(CHEMBL4875486)
Affinity DataIC50:  40nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50529040(CHEMBL4529727)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged Bcl-xl (1 to 209 residues) expressed in Escherichia coli using HyLite Fluor 647-labeled BIM pep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573119(CHEMBL4850040)
Affinity DataIC50:  40nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50573124(CHEMBL4851329)
Affinity DataIC50:  50nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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