TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Oncology Innovative Medicines Unit
Oncology Innovative Medicines Unit
Affinity DataKi: 0.900nM ΔG°: -51.5kJ/mole IC50: 3.40nMpH: 7.4 T: 2°CAssay Description:TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe....More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Oncology Innovative Medicines Unit
Oncology Innovative Medicines Unit
Affinity DataKi: 1.20nM ΔG°: -50.7kJ/mole IC50: 4.20nMpH: 7.4 T: 2°CAssay Description:TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe....More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Oncology Innovative Medicines Unit
Oncology Innovative Medicines Unit
Affinity DataKi: 1.20nM ΔG°: -50.7kJ/mole IC50: 4.70nMpH: 7.4 T: 2°CAssay Description:TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe....More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Oncology Innovative Medicines Unit
Oncology Innovative Medicines Unit
Affinity DataKi: 1.60nM ΔG°: -50.0kJ/mole IC50: 5.96nMpH: 7.4 T: 2°CAssay Description:TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe....More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Oncology Innovative Medicines Unit
Oncology Innovative Medicines Unit
Affinity DataKi: 16nM ΔG°: -44.3kJ/mole IC50: 59.5nMpH: 7.4 T: 2°CAssay Description:TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe....More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Oncology Innovative Medicines Unit
Oncology Innovative Medicines Unit
Affinity DataKi: 44nM ΔG°: -41.8kJ/mole IC50: 162nMpH: 7.4 T: 2°CAssay Description:TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe....More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Oncology Innovative Medicines Unit
Oncology Innovative Medicines Unit
Affinity DataKi: 64nM ΔG°: -40.9kJ/mole IC50: 237nMpH: 7.4 T: 2°CAssay Description:TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe....More data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Oncology Innovative Medicines Unit
Oncology Innovative Medicines Unit
Affinity DataKi: 104nM ΔG°: -39.7kJ/mole IC50: 383nMpH: 7.4 T: 2°CAssay Description:TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe....More data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human C-terminal 6xHis-tagged Bcl-2 (M1 to F212 residues) expressed in Escherichia coli using HyLite Fluor 647-labeled BIM ...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.20nMAssay Description:Inhibition of PRMT5 in human HCT116-MTAP null cells assessed as reduction in symmetric dimethylation of arginine using SAM as substrate incubated for...More data for this Ligand-Target Pair
Affinity DataIC50: 6.30nMAssay Description:Inhibition of PRMT5 in human HCT116-MTAP null cells assessed as reduction in symmetric dimethylation of arginine using SAM as substrate incubated for...More data for this Ligand-Target Pair
Affinity DataIC50: 7.90nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: <8nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged Bcl-xl (1 to 209 residues) expressed in Escherichia coli using HyLite Fluor 647-labeled BIM pep...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of PRMT5 in human HCT116-MTAP null cells assessed as reduction in symmetric dimethylation of arginine using SAM as substrate incubated for...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of PRMT5 in human HCT116-MTAP null cells assessed as reduction in symmetric dimethylation of arginine using SAM as substrate incubated for...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged Bcl-xl (1 to 209 residues) expressed in Escherichia coli using HyLite Fluor 647-labeled BIM pep...More data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of FLAG-tagged AXL (unknown origin) transfected in Cos-7 cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of AXL (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged Bcl-xl (1 to 209 residues) expressed in Escherichia coli using HyLite Fluor 647-labeled BIM pep...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair