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Target
Putative FAD-containing monooxygenase MymA
Ligand
BDBM50336507
Substrate
n/a
Meas. Tech.
MymA Inhibition Assay
IC50
4.9e+3±n/a nM
Citation
 Saraav, I; Pandey, K; Misra, R; Singh, S; Sharma, M; Sharma, S Characterization of MymA protein as a flavin-containing monooxygenase and as a target of isoniazid. Chem Biol Drug Des 89:152-160 (2017) [PubMed]  Article 
Target
Name:
Putative FAD-containing monooxygenase MymA
Synonyms:
MYMA_MYCTU | mymA
Type:
Protein
Mol. Mass.:
55489.29
Organism:
Mycobacterium tuberculosis
Description:
P9WNF7
Residue:
495
Sequence:
MNQHFDVLIIGAGLSGIGTACHVTAEFPDKTIALLERRERLGGTWDLFRYPGVRSDSDMFTFGYKFRPWRDVKVLADGASIRQYIADTATEFGVDEKIHYGLKVNTAEWSSRQCRWTVAGVHEATGETRTYTCDYLISCTGYYNYDAGYLPDFPGVHRFGGRCVHPQHWPEDLDYSGKKVVVIGSGATAVTLVPAMAGSNPGSAAHVTMLQRSPSYIFSLPAVDKISEVLGRFLPDRWVYEFGRRRNIAIQRKLYQACRRWPKLMRRLLLWEVRRRLGRSVDMSNFTPNYLPWDERLCAVPNGDLFKTLASGAASVVTDQIETFTEKGILCKSGREIEADIIVTATGLNIQMLGGMRLIVDGAEYQLPEKMTYKGVLLENAPNLAWIIGYTNASWTLKSDIAGAYLCRLLRHMADNGYTVATPRDAQDCALDVGMFDQLNSGYVKRGQDIMPRQGSKHPWRVLMHYEKDAKILLEDPIDDGVLHFAAAAQDHAAA
  
Inhibitor
Name:
BDBM50336507
Synonyms:
4-pyridinecarbohydrazide(Isoniazid) | CHEMBL64 | Dow-isoniazid | Hyzyd | INH | ISONICOTINIC ACID HYDRAZIDE(ISONIAZIDE) | Isoniazid (INH) | Isonicotinic acid hydrazide (Isoniazid) | Isonicotinic acid hydrazide(Isoniazid) | Isonicotinylhydrazine | Laniazid | Nydrazid | Rimifon | Stanozide | isoniazid | isonicotinamide | isonicotinhydrazide | isonicotinohydrazide | isonicotinyl hydrazide | pyridine-4-carbohydrazide
Type:
Small organic molecule
Emp. Form.:
C6H7N3O
Mol. Mass.:
137.1393
SMILES:
NNC(=O)c1ccncc1
Structure:
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