Reaction Details Report a problem with these data
Target
Fanconi anemia group J protein
Ligand
BDBM213234
Substrate
5' Poly A Zic 1
Meas. Tech.
Helicase Assays
pH
8±n/a
IC50
0.13±0.05 nM
Comments
extracted
Citation
 Bharti, SK; Sommers, JA; George, F; Kuper, J; Hamon, F; Shin-ya, K; Teulade-Fichou, MP; Kisker, C; Brosh, RM Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability. J Biol Chem 288:28217-29 (2013) [PubMed]  Article 
Target
Name:
Fanconi anemia group J protein
Synonyms:
BACH1 | BRIP1 | FANCJ | FANCJ_HUMAN | Fe-S helicase (FANCJ)
Type:
Enzyme
Mol. Mass.:
140883.49
Organism:
Homo sapiens (Human)
Description:
Q9BX63
Residue:
1249
Sequence:
MSSMWSEYTIGGVKIYFPYKAYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSALAWQQSLSGKPADEGVSEKAEVQLSCCCACHSKDFTNNDMNQGTSRHFNYPSTPPSERNGTSSTCQDSPEKTTLAAKLSAKKQASIYRDENDDFQVEKKRIRPLETTQQIRKRHCFGTEVHNLDAKVDSGKTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMTILSSRDHTCVHPEVVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAEYLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGRQWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKATPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKIDATLTRKNHSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEKNDLAETDRGNRLANNSDCILAKDLFEIRTIKEVDSAREVKAEDCIDTKLNGILHIEESKIDDIDGNVKTTWINELELGKTHEIEIKNFKPSPSKNKGMFPGFK
  
Inhibitor
Name:
BDBM213234
Synonyms:
Phen-DC6
Type:
Small organic molecule
Emp. Form.:
C34H26N6O2
Mol. Mass.:
550.6081
SMILES:
C[n+]1cccc2cc(NC(=O)c3ccc4ccc5ccc(nc5c4n3)C(=O)Nc3ccc4[n+](C)cccc4c3)ccc12
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
5' Poly A Zic 1
Synonyms:
n/a
Type:
DNA
Mol. Mass.:
3261.42
Organism:
n/a
Description:
G4 DNA substrate
Residue:
48
Sequence:
AAAAAAAAAAAAAAAAAAAGGGTGGGGGGGCGGGGGAGGCCGGGGAAA