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Target
Thymidine phosphorylase
Ligand
BDBM50134399
Substrate
n/a
Meas. Tech.
Thymidine Phosphorylase Inhibition Assay
Temperature
303.15±n/a K
IC50
4.10e+4± 1.63e+3 nM
Comments
extracted
Citation
 Javaid, S; Ishtiaq, M; Shaikh, M; Hameed, A; Choudhary, MI Thymidine esters as substrate analogue inhibitors of angiogenic enzyme thymidine phosphorylase in vitro. Bioorg Chem 70:44-56 (2017) [PubMed]  Article 
Target
Name:
Thymidine phosphorylase
Synonyms:
TYPH_ECOLI | TdRPase | Thymidine Phosphorylase (TP) | deoA | tpp | ttg
Type:
Enzyme
Mol. Mass.:
47198.54
Organism:
Escherichia coli
Description:
n/a
Residue:
440
Sequence:
MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALGMAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENNWQEAAKAVKAAIKLADKAPESTPTVYRRISE
  
Inhibitor
Name:
BDBM50134399
Synonyms:
1,7-Dihydro-pyrrolo[2,3-d]pyrimidine-2,4-dione | 7-Deazaxanthine (7DX) | 7-deazaxanthine | CHEMBL122899
Type:
Small organic molecule
Emp. Form.:
C6H5N3O2
Mol. Mass.:
151.1228
SMILES:
O=c1[nH]c2[nH]ccc2c(=O)[nH]1
Structure:
Search PDB for entries with ligand similarity: