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Target
Transcription factor SOX-18
Ligand
BDBM223297
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
pH
7.5±n/a
Temperature
310.15±n/a K
IC50
2.880e+6± 1.1e+3 nM
Comments
extracted
Citation
 Fontaine, F; Overman, J; Moustaqil, M; Mamidyala, S; Salim, A; Narasimhan, K; Prokoph, N; Robertson, AA; Lua, L; Alexandrov, K; Koopman, P; Capon, RJ; Sierecki, E; Gambin, Y; Jauch, R; Cooper, MA; Zuegg, J; Francois, M Small-Molecule Inhibitors of the SOX18 Transcription Factor. Cell Chem Biol 24:346-359 (2017) [PubMed]  Article 
Target
Name:
Transcription factor SOX-18
Synonyms:
SOX18_MOUSE | Sox-18 | Sox18 | Transcription factor SOX-18 (SOX-18)
Type:
Protein
Mol. Mass.:
40900.72
Organism:
Mus musculus (Mouse)
Description:
P43680
Residue:
377
Sequence:
MQRSPPGYGAQDDPPSRRDCAWAPGIGAAAEARGLPVTNVSPTSPASPSSLPRSPPRSPESGRYGFGRGERQTADELRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNTAEKRPFVEEAERLRVQHLRDHPNYKYRPRRKKQARKVRRLEPGLLLPGLVQPSAPPEAFAAASGSARSFRELPTLGAEFDGLGLPTPERSPLDGLEPGEASFFPPPLAPEDCALRAFRAPYAPELARDPSFCYGAPLAEALRTAPPAAPLAGLYYGTLGTPGPFPNPLSPPPESPSLEGTEQLEPTADLWADVDLTEFDQYLNCSRTRPDATTLPYHVALAKLGPRAMSCPEESSLISALSDASSAVYYSACISG
  
Inhibitor
Name:
BDBM223297
Synonyms:
Sm12 | US20240002326, Compound Sm12
Type:
Small organic molecule
Emp. Form.:
C18H14O4
Mol. Mass.:
294.3014
SMILES:
Oc1ccc(C(=O)COc2ccc3ccccc3c2)c(O)c1
Structure:
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