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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50347988
Substrate
n/a
Meas. Tech.
125I-Leuprorelin Binding Assay
IC50
9±n/a nM
Citation
 Cho, N; Imada, T; Hitaka, T; Miwa, K; Kusaka, M; Suzuki, N Thienopyrimidine compounds and use thereof US Patent  US9346822 Publication Date 5/24/2016 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37832.65
Organism:
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Description:
G7P5Q7
Residue:
328
Sequence:
MANSASPEQNQNHCSVINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKEKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSSSKLGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFPQWWHQAFYNFFTFSCLFIIPLLIMLICNAKIIFTLTRVLHQDPHKLQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRVSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50347988
Synonyms:
CHEMBL1800152 | US9346822, 40
Type:
Small organic molecule
Emp. Form.:
C31H30F2N6O5S
Mol. Mass.:
636.669
SMILES:
COCCN(C)Cc1c(sc2n(Cc3c(F)cccc3F)c(=O)n(-c3ccccn3)c(=O)c12)-c1ccc(NC(=O)NOC)cc1
Structure:
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