Reaction Details Report a problem with these data
Target
Plasmepsin II
Ligand
BDBM50001676
Substrate
n/a
Meas. Tech.
Fluorescence Resonance Energy Transfer (FRET)-Based Assay
pH
5±n/a
IC50
1.65e+3±n/a nM
Comments
extracted
Citation
 Ahmed, W; Rani, M; Khan, IA; Iqbal, A; Khan, KM; Haleem, MA; Azim, MK Characterisation of hydrazides and hydrazine derivatives as novel aspartic protease inhibitors. J Enzyme Inhib Med Chem 25:673-8 (2010) [PubMed]  Article 
Target
Name:
Plasmepsin II
Synonyms:
Aspartic hemoglobinase II | PFAPD | PLM2_PLAFX | PMII | Plasmepsin 2 | Plasmepsin 2 (PM-II) | Plasmepsin-II
Type:
Enzyme
Mol. Mass.:
51482.09
Organism:
Plasmodium falciparum
Description:
P46925
Residue:
453
Sequence:
MDITVREHDFKHGFIKSNSTFDGLNIDNSKNKKKIQKGFQILYVLLFCSVMCGLFYYVYENVWLQRDNEMNEILKNSEHLTIGFKVENAHDRILKTIKTHKLKNYIKESVNFLNSGLTKTNYLGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKHLYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYTASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEERFYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDVIKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPVPTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL
  
Inhibitor
Name:
BDBM50001676
Synonyms:
CHEMBL3237776 | Mr-I-27
Type:
Small organic molecule
Emp. Form.:
C8H10N2O2
Mol. Mass.:
166.1772
SMILES:
COc1ccccc1C(=O)NN
Structure:
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