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Target
Cathepsin D
Ligand
BDBM233142
Substrate
n/a
Meas. Tech.
Fluorescence Resonance Energy Transfer (FRET)-Based Assay
pH
5±n/a
IC50
2.5e+3±n/a nM
Comments
extracted
Citation
 Ahmed, W; Rani, M; Khan, IA; Iqbal, A; Khan, KM; Haleem, MA; Azim, MK Characterisation of hydrazides and hydrazine derivatives as novel aspartic protease inhibitors. J Enzyme Inhib Med Chem 25:673-8 (2010) [PubMed]  Article 
Target
Name:
Cathepsin D
Synonyms:
CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor
Type:
Enzyme
Mol. Mass.:
44551.72
Organism:
Homo sapiens (Human)
Description:
Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.
Residue:
412
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
  
Inhibitor
Name:
BDBM233142
Synonyms:
1,2-Dipyridinylhydrazine | Mr-II-80
Type:
Small organic molecule
Emp. Form.:
C10H10N4
Mol. Mass.:
186.2132
SMILES:
N(Nc1ccncc1)c1ccncc1
Structure:
Search PDB for entries with ligand similarity: