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Target
Receptor-type tyrosine-protein kinase FLT3 [564-993]
Ligand
BDBM239026
Substrate
BioDB n*24 SEQ ID NO: 1
Meas. Tech.
Biochemical Assay
pH
7.9±n/a
Temperature
301.15±n/a K
IC50
<50±n/a nM
Comments
extracted
Citation
 Lombardi Borgia, A; Ciomei, M; Donati, D; Nesi, M Substituted indazole derivatives active as kinase inhibitors US Patent  US9408850 Publication Date 8/9/2016 
Target
Name:
Receptor-type tyrosine-protein kinase FLT3 [564-993]
Synonyms:
CD135 | FLK2 | FLT3 | FLT3_HUMAN | Receptor-type tyrosine-protein kinase FLT3 | STK1
Type:
Protein
Mol. Mass.:
49684.10
Organism:
Homo sapiens (Human)
Description:
aa 564-993
Residue:
430
Sequence:
HKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS
  
Inhibitor
Name:
BDBM239026
Synonyms:
US10028934, Compound 40 | US10478423, Cpd. 40 | US9408850, 40 | US9597317, 40
Type:
Small organic molecule
Emp. Form.:
C29H33N5O4
Mol. Mass.:
515.6034
SMILES:
COc1ccc(COCCOc2ccc3c(NC(=O)c4ccc(cc4)N4CCN(C)CC4)n[nH]c3c2)cc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BioDB n*24 SEQ ID NO: 1
Synonyms:
n/a
Type:
Peptide Substrate
Mol. Mass.:
2821.27
Organism:
Artificial Organism
Description:
SEQ ID NO: 1
Residue:
25
Sequence:
GGKKKVSRSGLYRSPSMPENLNRPR