Reaction Details Report a problem with these data
Target
Carbonic anhydrase 1
Ligand
BDBM246518
Substrate
BDBM246520
Meas. Tech.
Hydratase and Esterase Activity Assays
Ki
4.6e+4± 5.4e+3 nM
IC50
2.66e+5±n/a nM
Citation
Akbaba, Y; Akincioglu, A; Göçer, H; Göksu, S; Gülçin, I; Supuran, CT Carbonic anhydrase inhibitory properties of novel sulfonamide derivatives of aminoindanes and aminotetralins. J Enzyme Inhib Med Chem 29:35-42 (2014) [PubMed] Article
More Info.:
Target
Name:
Carbonic anhydrase 1
Synonyms:
CA-I | CA1 | CAB | CAH1_HUMAN | Carbonate dehydratase I | Carbonic anhydrase | Carbonic anhydrase 1 (CA I) | Carbonic anhydrase 1 (CA-I) | Carbonic anhydrase 1 (Recombinant CA I) | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase B | Carbonic anhydrase I | Carbonic anhydrase I (CA I) | Carbonic anhydrase I (CA-I) | Carbonic anhydrase I (CAI) | Carbonic anhydrase I (hCA I) | Carbonic anhydrase isoenzyme I (hCA I) | hCA
Type:
Enzyme
Mol. Mass.:
28873.37
Organism:
Homo sapiens (Human)
Description:
P00915
Residue:
261
Sequence:
MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF
Inhibitor
Name:
BDBM246518
Synonyms:
N-(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methanesulfonamide (32)
Type:
Small organic molecule
Emp. Form.:
C12H17NO4S
Mol. Mass.:
271.333
SMILES:
COc1cc2CC(Cc2cc1OC)NS(C)(=O)=O