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Target
Tyrosine-protein kinase Lck
Ligand
BDBM6619
Substrate
N-biotinyl peptide substrate
Meas. Tech.
Tyrosine Kinase Assay
pH
7±n/a
Temperature
295.15±n/a K
IC50
2300±n/a nM
Citation
 Honma, T; Yoshizumi, T; Hashimoto, N; Hayashi, K; Kawanishi, N; Fukasawa, K; Takaki, T; Ikeura, C; Ikuta, M; Suzuki-Takahashi, I; Hayama, T; Nishimura, S; Morishima, H A novel approach for the development of selective Cdk4 inhibitors: library design based on locations of Cdk4 specific amino acid residues. J Med Chem 44:4628-40 (2001) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Lck
Synonyms:
2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:
n/a
Mol. Mass.:
57987.83
Organism:
Homo sapiens (Human)
Description:
P06239
Residue:
509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP
  
Inhibitor
Name:
BDBM6619
Synonyms:
3-[(9bR)-5-oxo-1H,2H,3H,5H,9bH-benzo[a]pyrrolizin-9-yl]-1-pyridin-2-ylurea | CHEMBL141247 | N -(pyrrolidino[2,1-b]isoindolin-4-on-8-yl)-N-(pyridin-2yl)urea | Pyridin-2-yl urea | diarylurea deriv. 1
Type:
Small organic molecule
Emp. Form.:
C17H16N4O2
Mol. Mass.:
308.3345
SMILES:
O=C(Nc1ccccn1)Nc1cccc2C(=O)N3CCC[C@@H]3c12 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
N-biotinyl peptide substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
3583.82
Organism:
n/a
Description:
n/a
Residue:
31
Sequence:
NAMINHEANYLITINEQEDEPEGIYGVLFNH