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Target
5-hydroxytryptamine receptor 3A
Ligand
BDBM410099
Substrate
n/a
Meas. Tech.
Competition Binding Assay
Ki
32.0±n/a nM
Citation
 Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; McRiner, AJ Aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors US Patent  US10370370 Publication Date 8/6/2019 
Target
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3
Type:
Protein
Mol. Mass.:
55283.27
Organism:
Homo sapiens (Human)
Description:
P46098
Residue:
478
Sequence:
MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
  
Inhibitor
Name:
BDBM410099
Synonyms:
US10370370, Compound 3-P1
Type:
Small organic molecule
Emp. Form.:
C14H16ClN3O
Mol. Mass.:
277.749
SMILES:
Clc1ccc2c(NC3CN4CCC3CC4)noc2c1 |(9.64,-3.27,;8.16,-3.67,;7.25,-2.42,;5.72,-2.58,;5.09,-3.99,;3.63,-4.47,;2.3,-3.7,;.96,-4.47,;.96,-6.01,;-.37,-6.78,;-1.71,-6.01,;-1.71,-4.47,;-.37,-3.7,;.4,-5.03,;-1.09,-5.43,;3.63,-6.01,;5.09,-6.48,;6,-5.24,;7.53,-5.08,)|
Structure:
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