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Target
5-hydroxytryptamine receptor 3A
Ligand
BDBM410107
Substrate
n/a
Meas. Tech.
Competition Binding Assay
Ki
410±n/a nM
Citation
 Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; McRiner, AJ Aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors US Patent  US10370370 Publication Date 8/6/2019 
Target
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3
Type:
Protein
Mol. Mass.:
55283.27
Organism:
Homo sapiens (Human)
Description:
P46098
Residue:
478
Sequence:
MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
  
Inhibitor
Name:
BDBM410107
Synonyms:
US10370370, Compound 6-P2
Type:
Small organic molecule
Emp. Form.:
C17H21N3O
Mol. Mass.:
283.3681
SMILES:
C1CC1c1ccc2c(N[C@@H]3CN4CCC3CC4)noc2c1 |r,wD:9.9,(9.83,-3.39,;9.51,-1.89,;8.37,-2.92,;6.86,-3.24,;5.83,-2.09,;4.33,-2.41,;3.85,-3.88,;2.44,-4.51,;1.11,-3.74,;-.22,-4.51,;-.22,-6.05,;-1.56,-6.82,;-2.89,-6.05,;-2.89,-4.51,;-1.56,-3.74,;-.79,-5.07,;-2.28,-5.47,;2.6,-6.04,;4.11,-6.36,;4.88,-5.02,;6.39,-4.7,)|
Structure:
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