Reaction Details Report a problem with these data
Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM410112
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
59.5±n/a nM
Citation
 Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; McRiner, AJ Aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors US Patent  US10370370 Publication Date 8/6/2019 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM410112
Synonyms:
US10370370, Compound 9-P1
Type:
Small organic molecule
Emp. Form.:
C14H15Cl2N3O
Mol. Mass.:
312.194
SMILES:
Clc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1Cl |r,wU:7.6,(9.64,-2.82,;8.14,-3.14,;7.11,-1.99,;5.6,-2.31,;5.13,-3.78,;3.72,-4.4,;2.38,-3.63,;1.05,-4.4,;1.05,-5.94,;-.28,-6.71,;-1.62,-5.94,;-1.62,-4.4,;-.28,-3.63,;.49,-4.97,;-1,-5.36,;3.88,-5.93,;5.39,-6.25,;6.16,-4.92,;7.66,-4.6,;8.69,-5.75,)|
Structure:
Search PDB for entries with ligand similarity: