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Target
5-hydroxytryptamine receptor 3A
Ligand
BDBM410116
Substrate
n/a
Meas. Tech.
Competition Binding Assay
Ki
740±n/a nM
Citation
 Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; McRiner, AJ Aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors US Patent  US10370370 Publication Date 8/6/2019 
Target
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3
Type:
Protein
Mol. Mass.:
55283.27
Organism:
Homo sapiens (Human)
Description:
P46098
Residue:
478
Sequence:
MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
  
Inhibitor
Name:
BDBM410116
Synonyms:
US10370370, Compound (R)-12
Type:
Small organic molecule
Emp. Form.:
C15H16N4O
Mol. Mass.:
268.3137
SMILES:
N#Cc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1 |r,wU:8.7,TLB:7:8:11.12:14.15,(4.24,-.9,;2.77,-1.38,;1.31,-1.85,;.16,-.82,;-1.3,-1.3,;-1.62,-2.81,;-2.96,-3.58,;-4.48,-2.98,;-5.75,-4,;-5.45,-5.51,;-6.93,-4.82,;-6.66,-2.76,;-7.14,-1.56,;-7.22,-3.34,;-8.81,-4.03,;-8.59,-5.53,;-2.64,-5.08,;-1.11,-5.24,;-.48,-3.84,;.99,-3.36,)|
Structure:
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