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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM410127
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
580±n/a nM
Citation
 Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; McRiner, AJ Aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors US Patent  US10370370 Publication Date 8/6/2019 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM410127
Synonyms:
US10370370, Compound (R)-20
Type:
Small organic molecule
Emp. Form.:
C15H18FN3O
Mol. Mass.:
275.3213
SMILES:
Cc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1F |r,wU:7.6,TLB:6:7:10.11:13.14,(2.96,-.49,;1.6,-1,;.41,-.03,;-1.03,-.57,;-1.28,-2.09,;-2.58,-2.91,;-4.01,-2.35,;-5.22,-3.31,;-4.93,-4.73,;-6.33,-4.09,;-6.07,-2.15,;-6.53,-1.02,;-6.6,-2.69,;-8.1,-3.35,;-7.9,-4.76,;-2.35,-4.44,;-.9,-4.52,;-.09,-3.06,;1.35,-2.52,;2.47,-3.45,)|
Structure:
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