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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM410137
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
280±n/a nM
Citation
 Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; McRiner, AJ Aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors US Patent  US10370370 Publication Date 8/6/2019 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM410137
Synonyms:
US10370370, Compound (R)-30
Type:
Small organic molecule
Emp. Form.:
C15H18ClN3O2
Mol. Mass.:
307.775
SMILES:
COc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1Cl |r,wU:8.7,TLB:7:8:11.12:14.15,(3.32,1.08,;3.08,-.36,;1.72,-.87,;.54,.11,;-.91,-.43,;-1.16,-1.95,;-2.46,-2.77,;-3.89,-2.21,;-5.1,-3.17,;-4.81,-4.59,;-6.21,-3.95,;-5.95,-2.01,;-6.4,-.88,;-6.47,-2.55,;-7.97,-3.21,;-7.77,-4.62,;-2.23,-4.3,;-.78,-4.39,;.03,-2.92,;1.47,-2.38,;2.59,-3.31,)|
Structure:
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