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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM410139
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
29.0±n/a nM
Citation
 Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; McRiner, AJ Aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors US Patent  US10370370 Publication Date 8/6/2019 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM410139
Synonyms:
US10370370, Compound (R)-31
Type:
Small organic molecule
Emp. Form.:
C15H18ClN3O
Mol. Mass.:
291.776
SMILES:
Cc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1Cl |r,wU:7.6,TLB:6:7:10.11:13.14,(3.34,-.16,;1.98,-.67,;.79,.31,;-.65,-.23,;-.9,-1.75,;-2.2,-2.58,;-3.63,-2.02,;-4.84,-2.98,;-4.55,-4.4,;-5.95,-3.75,;-5.69,-1.81,;-6.15,-.68,;-6.22,-2.35,;-7.72,-3.01,;-7.52,-4.42,;-1.97,-4.1,;-.52,-4.19,;.29,-2.73,;1.73,-2.19,;2.85,-3.11,)|
Structure:
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