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Target
5-hydroxytryptamine receptor 3A
Ligand
BDBM410147
Substrate
n/a
Meas. Tech.
Competition Binding Assay
Ki
120±n/a nM
Citation
 Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; McRiner, AJ Aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors US Patent  US10370370 Publication Date 8/6/2019 
Target
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3
Type:
Protein
Mol. Mass.:
55283.27
Organism:
Homo sapiens (Human)
Description:
P46098
Residue:
478
Sequence:
MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
  
Inhibitor
Name:
BDBM410147
Synonyms:
US10370370, Compound (R)-39
Type:
Small organic molecule
Emp. Form.:
C16H20ClN3O2
Mol. Mass.:
321.802
SMILES:
CCOc1c(Cl)ccc2c(N[C@H]3CN4CCC3CC4)noc12 |r,wU:11.10,TLB:10:11:14.15:17.18,(1.61,-4.72,;2.97,-4.21,;3.21,-2.78,;2.09,-1.86,;2.34,-.34,;3.7,.17,;1.15,.64,;-.29,.1,;-.55,-1.42,;-1.84,-2.25,;-3.28,-1.68,;-4.48,-2.64,;-4.2,-4.07,;-5.59,-3.42,;-5.33,-1.48,;-5.79,-.35,;-5.86,-2.02,;-7.36,-2.68,;-7.16,-4.09,;-1.62,-3.77,;-.17,-3.86,;.64,-2.4,)|
Structure:
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