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Target
5-hydroxytryptamine receptor 3A
Ligand
BDBM410149
Substrate
n/a
Meas. Tech.
Competition Binding Assay
Ki
670±n/a nM
Citation
 Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; McRiner, AJ Aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors US Patent  US10370370 Publication Date 8/6/2019 
Target
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3
Type:
Protein
Mol. Mass.:
55283.27
Organism:
Homo sapiens (Human)
Description:
P46098
Residue:
478
Sequence:
MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
  
Inhibitor
Name:
BDBM410149
Synonyms:
US10370370, Compound (S)-41
Type:
Small organic molecule
Emp. Form.:
C14H15ClFN3O
Mol. Mass.:
295.74
SMILES:
Fc1c(Cl)ccc2c(N[C@@H]3CN4CCC3CC4)noc12 |r,wD:9.8,TLB:8:9:12.13:15.16,(3.41,-2.59,;2.29,-1.67,;2.54,-.15,;3.9,.36,;1.35,.83,;-.09,.29,;-.34,-1.23,;-1.64,-2.06,;-3.08,-1.49,;-4.28,-2.45,;-3.99,-3.88,;-5.39,-3.23,;-5.13,-1.29,;-5.59,-.16,;-5.66,-1.83,;-7.16,-2.49,;-6.96,-3.9,;-1.41,-3.58,;.04,-3.67,;.85,-2.21,)|
Structure:
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