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Target
5-hydroxytryptamine receptor 3A
Ligand
BDBM410151
Substrate
n/a
Meas. Tech.
Competition Binding Assay
Ki
980±n/a nM
Citation
 Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; McRiner, AJ Aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors US Patent  US10370370 Publication Date 8/6/2019 
Target
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3
Type:
Protein
Mol. Mass.:
55283.27
Organism:
Homo sapiens (Human)
Description:
P46098
Residue:
478
Sequence:
MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
  
Inhibitor
Name:
BDBM410151
Synonyms:
US10370370, Compound (S)-42
Type:
Small organic molecule
Emp. Form.:
C14H15ClFN3O
Mol. Mass.:
295.74
SMILES:
Fc1cc2c(N[C@@H]3CN4CCC3CC4)noc2cc1Cl |r,wD:6.5,TLB:5:6:9.10:12.13,(1.68,2.31,;1.44,.88,;0,.34,;-.25,-1.18,;-1.55,-2.01,;-2.98,-1.45,;-4.19,-2.41,;-3.9,-3.83,;-5.3,-3.18,;-5.04,-1.25,;-5.5,-.11,;-5.57,-1.79,;-7.07,-2.44,;-6.87,-3.85,;-1.32,-3.53,;.13,-3.62,;.94,-2.16,;2.38,-1.62,;2.63,-.1,;3.99,.41,)|
Structure:
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