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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM410152
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
930±n/a nM
Citation
 Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; McRiner, AJ Aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors US Patent  US10370370 Publication Date 8/6/2019 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM410152
Synonyms:
US10370370, Compound (R)-43
Type:
Small organic molecule
Emp. Form.:
C14H16BrN3O
Mol. Mass.:
322.2
SMILES:
Brc1ccc2c(N[C@H]3CN4CCC3CC4)noc2c1 |r,wU:7.6,TLB:6:7:10.11:13.14,(4.08,.45,;2.72,-.06,;1.53,.92,;.09,.38,;-.16,-1.14,;-1.46,-1.97,;-2.9,-1.4,;-4.1,-2.36,;-3.82,-3.79,;-5.21,-3.14,;-4.95,-1.2,;-5.41,-.07,;-5.48,-1.74,;-6.98,-2.4,;-6.78,-3.81,;-1.23,-3.49,;.22,-3.58,;1.02,-2.12,;2.47,-1.58,)|
Structure:
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