Reaction Details Report a problem with these data
Target
Type-2 angiotensin II receptor
Ligand
BDBM318758
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
IC50
58.8±n/a nM
Citation
 McCarthy, TD; Naylor, A Heterocyclic compounds and methods of their use US Patent  US10370388 Publication Date 8/6/2019 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
  
Inhibitor
Name:
BDBM318758
Synonyms:
(2S,4S)-1-(2,2-diphenylacetyl)-4-((R)-3-phenylpiperidin-1-yl)pyrrolidine-2-carboxylic acid | US10370388, Compound 49 | US9624243, 49
Type:
Small organic molecule
Emp. Form.:
C30H32N2O3
Mol. Mass.:
468.5867
SMILES:
OC(=O)[C@@H]1C[C@@H](CN1C(=O)C(c1ccccc1)c1ccccc1)N1CCC[C@@H](C1)c1ccccc1
Structure:
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