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Target
Type-2 angiotensin II receptor
Ligand
BDBM318815
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
IC50
89.0±n/a nM
Citation
 McCarthy, TD; Naylor, A Heterocyclic compounds and methods of their use US Patent  US10370388 Publication Date 8/6/2019 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
  
Inhibitor
Name:
BDBM318815
Synonyms:
(2S,4S)-1-(2,2-diphenylacetyl)-44(3-(4-fluorophenyl)propyl)(methyl)amino)pyrrolidine-2-carboxamide | US10370388, Compound 136 | US9624243, 136
Type:
Small organic molecule
Emp. Form.:
C29H32FN3O2
Mol. Mass.:
473.5817
SMILES:
CN(CCCc1ccc(F)cc1)[C@H]1C[C@H](N(C1)C(=O)C(c1ccccc1)c1ccccc1)C(N)=O
Structure:
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