Reaction Details Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM425897
Substrate
n/a
Meas. Tech.
In-Vitro Efficacy of mPEG-O-Opioid Conjugates to Inhibit cAMP Formation
EC50
4198±n/a nM
Citation
 Riggs-Sauthier, J; Deng, B; Riley, TA Oligomer-opioid agonist conjugates US Patent  US10512644 Publication Date 12/24/2019 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM425897
Synonyms:
US10512644, Compound alpha-6-mPEG3-O-Morphine
Type:
Small organic molecule
Emp. Form.:
C24H33NO6
Mol. Mass.:
431.5219
SMILES:
COCCOCCOCCO[C@H]1C=CC2C3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3C)c45 |r,c:12,TLB:22:30:14:28.26.27,18:17:14:28.26.27|
Structure:
Search PDB for entries with ligand similarity: