Reaction Details Report a problem with these data
Target
Histone-lysine N-methyltransferase SMYD3
Ligand
BDBM432362
Substrate
n/a
Meas. Tech.
SMYD3 Biochemical Assay
IC50
15298±n/a nM
Citation
Mitchell, LH; Bell, AS; Chesworth, R; Foley, MA; Kuntz, KW; Mills, JE; Munchhof, MJ Substituted piperidine compounds US Patent US10577363 Publication Date 3/3/2020
More Info.:
Target
Name:
Histone-lysine N-methyltransferase SMYD3
Synonyms:
SET and MYND domain-containing protein 3 | SMYD3 | SMYD3_HUMAN | ZMYND1 | ZNFN3A1 | Zinc finger MYND domain-containing protein 1
Type:
Enzyme
Mol. Mass.:
49101.22
Organism:
Homo sapiens (Human)
Description:
Q9H7B4-2
Residue:
428
Sequence:
MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS
Inhibitor
Name:
BDBM432362
Synonyms:
N-(1-((R)-3-((S)-2-aminopropanamido)-2- (4-hydroxy-3- iodobenzyl)propanoyl)piperidin-4-yl)-5- cyclopropylisoxazole-3-carboxamide | US10577363, Compound 61
Type:
Small organic molecule
Emp. Form.:
C25H34IN5O4
Mol. Mass.:
595.473
SMILES:
C[C@H](N)C(=O)NC[C@@H](Cc1ccc(O)c(I)c1)C(=O)N1CCC(CC1)NCc1cc(on1)C1CC1 |r|