Reaction Details Report a problem with these data
Target
RAR related orphan receptor B isoform 1
Ligand
BDBM438836
Substrate
n/a
Meas. Tech.
RORa, b, and g Binding Inhibitors
Ki
>12500±n/a nM
Citation
 Lugar, III, CW; Morphy, JR; Richardson, TI; Rudyk, HC; Sapmaz, S; Stites, RE Compounds useful for inhibiting ROR-gamma-t US Patent  US10603320 Publication Date 3/31/2020 
Target
Name:
RAR related orphan receptor B isoform 1
Synonyms:
NR1F2 | Q58EY0_HUMAN | RAR related orphan receptor B isoform 1 (RORB) | ROR-BETA | RORB | RZRB | cDNA, FLJ93970, Homo sapiens RAR-related orphan receptor B (RORB), mRNA
Type:
Protein
Mol. Mass.:
52081.05
Organism:
Human
Description:
Q58EY0
Residue:
459
Sequence:
MRAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPEIVNTLFPPLYKELFNPDCATGCK
  
Inhibitor
Name:
BDBM438836
Synonyms:
1'-[1-(4- Cyanophenyl)ethyl]- 5,5- spirocyclopropane-N- [(4- ethylsulfonylphenyl) methyl]spiro[4H- thieno[2,3-c]pyran- 7,4'-piperidine]-2- carboxamide isomer 1 | US10603320, Example 8
Type:
Small organic molecule
Emp. Form.:
C32H35N3O4S2
Mol. Mass.:
589.768
SMILES:
CCS(=O)(=O)c1ccc(CNC(=O)c2cc3CC4(CC4)OC4(CCN(CC4)C(C)c4ccc(cc4)C#N)c3s2)cc1
Structure:
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