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Found 375 with Last Name = 'lugar, iii' and Initial = 'cw'
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM498079((5'S)-N-{[5- (Ethylsulfonyl)pyridin- 2-yl]methyl}-...)
Affinity DataKi:  3.27nMAssay Description:Receptor competition binding assays are run in a buffer made up of DPBS (1 L) (Hyclone #SH30028.03), 2.2 g BSA Fraction v (Roche #9048-46-8), 100 mL ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM498077(N-[4- (Ethylsulfonyl)benzyl]- 5'-methyl-1-{1-[6- (...)
Affinity DataKi:  4.42nMAssay Description:Receptor competition binding assays are run in a buffer made up of DPBS (1 L) (Hyclone #SH30028.03), 2.2 g BSA Fraction v (Roche #9048-46-8), 100 mL ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM498074((5′S)—N-[4-(Ethylsulfonyl)benzyl]-5′-m...)
Affinity DataKi:  5.88nMAssay Description:Receptor competition binding assays are run in a buffer made up of DPBS (1 L) (Hyclone #SH30028.03), 2.2 g BSA Fraction v (Roche #9048-46-8), 100 mL ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM438836(1'-[1-(4- Cyanophenyl)ethyl]- 5,5- spirocyclopropa...)
Affinity DataKi:  6nMAssay Description:His-tagged human RAR-related orphan receptor alpha (hRORa), human RAR-related orphan receptor beta (hRORb), and human RAR-related orphan receptor gam...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM498076((5'S)-N-{[5- (Ethylsulfonyl)pyridin- 2-yl]methyl}-...)
Affinity DataKi:  6.04nMAssay Description:Receptor competition binding assays are run in a buffer made up of DPBS (1 L) (Hyclone #SH30028.03), 2.2 g BSA Fraction v (Roche #9048-46-8), 100 mL ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM438835(N-{[5-(Ethylsulfonyl)pyridin-2-yl]methyl}-1″...)
Affinity DataKi:  6.40nMAssay Description:His-tagged human RAR-related orphan receptor alpha (hRORa), human RAR-related orphan receptor beta (hRORb), and human RAR-related orphan receptor gam...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM438834(N-{[5-(Ethylsulfonyl)pyridin-2-yl]methyl}-5′...)
Affinity DataKi:  6.96nMAssay Description:His-tagged human RAR-related orphan receptor alpha (hRORa), human RAR-related orphan receptor beta (hRORb), and human RAR-related orphan receptor gam...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM498078(N-{[5- (Ethylsulfonyl)pyridin- 2-yl]methyl}-5'- me...)
Affinity DataKi:  10.8nMAssay Description:Receptor competition binding assays are run in a buffer made up of DPBS (1 L) (Hyclone #SH30028.03), 2.2 g BSA Fraction v (Roche #9048-46-8), 100 mL ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM498080(1-[(1S)-1-(4- Cyanophenyl)ethyl]- N-[4- (ethylsulf...)
Affinity DataKi:  15.8nMAssay Description:Receptor competition binding assays are run in a buffer made up of DPBS (1 L) (Hyclone #SH30028.03), 2.2 g BSA Fraction v (Roche #9048-46-8), 100 mL ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-beta(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM498081((5'S)-N-[4- (Ethylsulfonyl)benzyl]- 5'-methyl-1-{1...)
Affinity DataKi:  151nMAssay Description:Receptor competition binding assays are run in a buffer made up of DPBS (1 L) (Hyclone #SH30028.03), 2.2 g BSA Fraction v (Roche #9048-46-8), 100 mL ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-alpha(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM498081((5'S)-N-[4- (Ethylsulfonyl)benzyl]- 5'-methyl-1-{1...)
Affinity DataKi:  698nMAssay Description:Receptor competition binding assays are run in a buffer made up of DPBS (1 L) (Hyclone #SH30028.03), 2.2 g BSA Fraction v (Roche #9048-46-8), 100 mL ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-alpha(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM498076((5'S)-N-{[5- (Ethylsulfonyl)pyridin- 2-yl]methyl}-...)
Affinity DataKi:  1.05E+3nMAssay Description:Receptor competition binding assays are run in a buffer made up of DPBS (1 L) (Hyclone #SH30028.03), 2.2 g BSA Fraction v (Roche #9048-46-8), 100 mL ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-beta(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM498076((5'S)-N-{[5- (Ethylsulfonyl)pyridin- 2-yl]methyl}-...)
Affinity DataKi:  1.14E+3nMAssay Description:Receptor competition binding assays are run in a buffer made up of DPBS (1 L) (Hyclone #SH30028.03), 2.2 g BSA Fraction v (Roche #9048-46-8), 100 mL ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-alpha(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM498074((5′S)—N-[4-(Ethylsulfonyl)benzyl]-5′-m...)
Affinity DataKi:  3.11E+3nMAssay Description:Receptor competition binding assays are run in a buffer made up of DPBS (1 L) (Hyclone #SH30028.03), 2.2 g BSA Fraction v (Roche #9048-46-8), 100 mL ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-alpha(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM498080(1-[(1S)-1-(4- Cyanophenyl)ethyl]- N-[4- (ethylsulf...)
Affinity DataKi:  3.27E+3nMAssay Description:Receptor competition binding assays are run in a buffer made up of DPBS (1 L) (Hyclone #SH30028.03), 2.2 g BSA Fraction v (Roche #9048-46-8), 100 mL ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-alpha(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM438835(N-{[5-(Ethylsulfonyl)pyridin-2-yl]methyl}-1″...)
Affinity DataKi:  3.46E+3nMAssay Description:His-tagged human RAR-related orphan receptor alpha (hRORa), human RAR-related orphan receptor beta (hRORb), and human RAR-related orphan receptor gam...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-beta(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM498082((5'S)-N-{[5- (Ethylsulfonyl)pyridin- 2-yl]methyl}-...)
Affinity DataKi:  4.47E+3nMAssay Description:Receptor competition binding assays are run in a buffer made up of DPBS (1 L) (Hyclone #SH30028.03), 2.2 g BSA Fraction v (Roche #9048-46-8), 100 mL ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-beta(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM498078(N-{[5- (Ethylsulfonyl)pyridin- 2-yl]methyl}-5'- me...)
Affinity DataKi:  4.84E+3nMAssay Description:Receptor competition binding assays are run in a buffer made up of DPBS (1 L) (Hyclone #SH30028.03), 2.2 g BSA Fraction v (Roche #9048-46-8), 100 mL ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-alpha(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM438834(N-{[5-(Ethylsulfonyl)pyridin-2-yl]methyl}-5′...)
Affinity DataKi:  5.68E+3nMAssay Description:His-tagged human RAR-related orphan receptor alpha (hRORa), human RAR-related orphan receptor beta (hRORb), and human RAR-related orphan receptor gam...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-alpha(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM498082((5'S)-N-{[5- (Ethylsulfonyl)pyridin- 2-yl]methyl}-...)
Affinity DataKi:  9.53E+3nMAssay Description:Receptor competition binding assays are run in a buffer made up of DPBS (1 L) (Hyclone #SH30028.03), 2.2 g BSA Fraction v (Roche #9048-46-8), 100 mL ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-beta(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM498074((5′S)—N-[4-(Ethylsulfonyl)benzyl]-5′-m...)
Affinity DataKi: >1.25E+4nMAssay Description:Receptor competition binding assays are run in a buffer made up of DPBS (1 L) (Hyclone #SH30028.03), 2.2 g BSA Fraction v (Roche #9048-46-8), 100 mL ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-beta(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM498079((5'S)-N-{[5- (Ethylsulfonyl)pyridin- 2-yl]methyl}-...)
Affinity DataKi: >1.25E+4nMAssay Description:Receptor competition binding assays are run in a buffer made up of DPBS (1 L) (Hyclone #SH30028.03), 2.2 g BSA Fraction v (Roche #9048-46-8), 100 mL ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAR related orphan receptor B isoform 1(Human)
Eli Lilly

US Patent
LigandPNGBDBM438836(1'-[1-(4- Cyanophenyl)ethyl]- 5,5- spirocyclopropa...)
Affinity DataKi: >1.25E+4nMAssay Description:His-tagged human RAR-related orphan receptor alpha (hRORa), human RAR-related orphan receptor beta (hRORb), and human RAR-related orphan receptor gam...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAR related orphan receptor B isoform 1(Human)
Eli Lilly

US Patent
LigandPNGBDBM438835(N-{[5-(Ethylsulfonyl)pyridin-2-yl]methyl}-1″...)
Affinity DataKi: >1.25E+4nMAssay Description:His-tagged human RAR-related orphan receptor alpha (hRORa), human RAR-related orphan receptor beta (hRORb), and human RAR-related orphan receptor gam...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-beta(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM498077(N-[4- (Ethylsulfonyl)benzyl]- 5'-methyl-1-{1-[6- (...)
Affinity DataKi: >1.25E+4nMAssay Description:Receptor competition binding assays are run in a buffer made up of DPBS (1 L) (Hyclone #SH30028.03), 2.2 g BSA Fraction v (Roche #9048-46-8), 100 mL ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAR related orphan receptor B isoform 1(Human)
Eli Lilly

US Patent
LigandPNGBDBM438834(N-{[5-(Ethylsulfonyl)pyridin-2-yl]methyl}-5′...)
Affinity DataKi: >1.25E+4nMAssay Description:His-tagged human RAR-related orphan receptor alpha (hRORa), human RAR-related orphan receptor beta (hRORb), and human RAR-related orphan receptor gam...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-alpha(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM498079((5'S)-N-{[5- (Ethylsulfonyl)pyridin- 2-yl]methyl}-...)
Affinity DataKi:  1.93E+4nMAssay Description:Receptor competition binding assays are run in a buffer made up of DPBS (1 L) (Hyclone #SH30028.03), 2.2 g BSA Fraction v (Roche #9048-46-8), 100 mL ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-alpha(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM438836(1'-[1-(4- Cyanophenyl)ethyl]- 5,5- spirocyclopropa...)
Affinity DataKi: >2.04E+4nMAssay Description:His-tagged human RAR-related orphan receptor alpha (hRORa), human RAR-related orphan receptor beta (hRORb), and human RAR-related orphan receptor gam...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-alpha(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM498078(N-{[5- (Ethylsulfonyl)pyridin- 2-yl]methyl}-5'- me...)
Affinity DataKi: >2.04E+4nMAssay Description:Receptor competition binding assays are run in a buffer made up of DPBS (1 L) (Hyclone #SH30028.03), 2.2 g BSA Fraction v (Roche #9048-46-8), 100 mL ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-alpha(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM498077(N-[4- (Ethylsulfonyl)benzyl]- 5'-methyl-1-{1-[6- (...)
Affinity DataKi: >2.04E+4nMAssay Description:Receptor competition binding assays are run in a buffer made up of DPBS (1 L) (Hyclone #SH30028.03), 2.2 g BSA Fraction v (Roche #9048-46-8), 100 mL ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-beta(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM498080(1-[(1S)-1-(4- Cyanophenyl)ethyl]- N-[4- (ethylsulf...)
Affinity DataKi: >2.27E+4nMAssay Description:Receptor competition binding assays are run in a buffer made up of DPBS (1 L) (Hyclone #SH30028.03), 2.2 g BSA Fraction v (Roche #9048-46-8), 100 mL ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639724(3-[[6,7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indol-4-yl...)
Affinity DataIC50:  3.22nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639875((S)—N-(5,6-Dichloro-8-(cyanomethoxy)-9-(1H-py...)
Affinity DataIC50:  3.38nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639703(N-[6, 7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indol-4-yl...)
Affinity DataIC50:  3.56nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639763((S)—N-(5,6-Dichloro-8-(cyanomethoxy)-9-(1H-py...)
Affinity DataIC50:  3.76nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639676(3-[[6,7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indol-4-yl...)
Affinity DataIC50:  4.33nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639869(3-((6,7-Dichloro-2-(hydroxymethyl)-3-(1H-pyrazol-4...)
Affinity DataIC50:  4.74nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639655(6,7-Dichloro-N-(2-fluoroethyl)-3-(1H-pyrazol-4-yl)...)
Affinity DataIC50:  4.91nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639685(N-((6,7-Dichloro-4-(cyanomethoxy)-3-(1H-pyrazol-4-...)
Affinity DataIC50:  5.11nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639781(3-[[6,7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indazol-4-...)
Affinity DataIC50:  5.20nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639702(N-(6,7-Dichloro-3-(1H-pyrazol-4-yl)-1H-indol-4-yl)...)
Affinity DataIC50:  5.67nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639874((S)—N-(5,6-Dichloro-8-ethoxy-9-(1H-pyrazol-4-...)
Affinity DataIC50:  6.14nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639734(2-((6,7-Dichloro-2-(5-methyl-1,3,4-thiadiazol-2-yl...)
Affinity DataIC50:  6.77nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639879(3,4-Dichloro-1-(3-hydroxypropoxy)-10-(1H-pyrazol-4...)
Affinity DataIC50:  6.95nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639810(2-((6,7-Dichloro-2-(2-methoxyacetyl)-10-(1H-pyrazo...)
Affinity DataIC50:  7.20nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639768(N-(5,6-Dichloro-9-(1H-pyrazol-4-yl)-2,3-dihydro-1H...)
Affinity DataIC50:  7.69nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639870(6,7-Dichloro-9-(3-hydroxypropoxy)-2-methyl-10-(1H-...)
Affinity DataIC50:  7.89nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639811(US20230391786, Example 280)
Affinity DataIC50:  8.70nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639812(US20230391786, Example 281)
Affinity DataIC50:  8.90nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclic GMP-AMP synthase(Homo sapiens)
Eli Lilly

US Patent
LigandPNGBDBM639728(22-[6, 7-Dichloro-1-[1-(2-hydroxy ethyl)triazol-4-...)
Affinity DataIC50:  8.93nMAssay Description:In vitro inhibition assay of cGAS activity: Add a 5 μL mixture containing 10 mM Tris-Cl pH 7.5, 50 mM NaCl, 5 mM MgCl2, 1 mM DTT, 0.01% Triton X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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