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Target
Serine/threonine-protein kinase 17A
Ligand
BDBM441909
Substrate
n/a
Meas. Tech.
Activity Inhibition Assay
IC50
140±n/a nM
Citation
 Lee, K; Choi, G; Lee, NR; Park, SJ; Jung, ME; Kim, SJ; Yang, K; Lee, J Substituted pyrimidines for preventing or treating cancer and inflammatory diseases US Patent  US10647686 Publication Date 5/12/2020 
Target
Name:
Serine/threonine-protein kinase 17A
Synonyms:
DRAK1 | ST17A_HUMAN | STK17A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46544.04
Organism:
Homo sapiens (Human)
Description:
gi_109255245
Residue:
414
Sequence:
MIPLEKPGSGGSSPGATSGSGRAGRGLSGPCRPPPPPQARGLLTEIRAVVRTEPFQDGYSLCPGRELGRGKFAVVRKCIKKDSGKEFAAKFMRKRRKGQDCRMEIIHEIAVLELAQDNPWVINLHEVYETASEMILVLEYAAGGEIFDQCVADREEAFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLTSESPLGDIKIVDFGLSRILKNSEELREIMGTPEYVAPEILSYDPISMATDMWSIGVLTYVMLTGISPFLGNDKQETFLNISQMNLSYSEEEFDVLSESAVDFIRTLLVKKPEDRATAEECLKHPWLTQSSIQEPSFRMEKALEEANALQEGHSVPEINSDTDKSETKESIVTEELIVVTSYTLGQCRQSEKEKMEQKAISKRFKFEEPLLQEIPGEFIY
  
Inhibitor
Name:
BDBM441909
Synonyms:
US10647686, Comparative Example 8
Type:
Small organic molecule
Emp. Form.:
C13H16ClN5
Mol. Mass.:
277.753
SMILES:
Cc1cnc(Nc2ccc(Cl)cc2)nc1NCCN
Structure:
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