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Target
Mu-type opioid receptor
Ligand
BDBM450937
Substrate
n/a
Meas. Tech.
OPR Mu Antagonist Assay
IC50
5.5±n/a nM
Citation
 Roberts, E; Guerrero, MA; Urbano, M; Rosen, H; Jones, RM; Laxamana, CM; Zhao, X; Turtle, ED Kappa opioid receptor antagonists and products and methods related thereto US Patent  US10676469 Publication Date 6/9/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM450937
Synonyms:
US10676469, Compound 181 | US11124504, Cpd. No. 181
Type:
Small organic molecule
Emp. Form.:
C26H32N6O2
Mol. Mass.:
460.5713
SMILES:
C[C@@H]1C[C@@H](CCN1c1nc2c(cc(C)cc2c(C)c1-c1nc(C)no1)C#N)NC1CCOCC1 |r|
Structure:
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