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Target
Stimulator of interferon genes protein
Ligand
BDBM453549
Substrate
n/a
Meas. Tech.
STING Biochemical [3H]cGAMP Competition Assay
EC50
8644±n/a nM
Citation
 Altman, MD; Cash, BD; Chang, W; Cumming, JN; Haidle, AM; Henderson, TJ; Jewell, JP; Larsen, MA; Liang, R; Lim, J; Lu, M; Otte, RD; Siu, T; Trotter, BW; Tyagarajan, S Benzo[b]thiophene compounds as STING agonists US Patent  US10730849 Publication Date 8/4/2020 
Target
Name:
Stimulator of interferon genes protein
Synonyms:
ERIS | Endoplasmic reticulum interferon stimulator | MITA | Mediator of IRF3 activation | STING | STING1 | STING_HUMAN | Synonyms=ERIS | TMEM173 | Transmembrane protein 173 | hMITA | hSTING
Type:
Protein
Mol. Mass.:
42195.64
Organism:
Human
Description:
Q86WV6
Residue:
379
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM453549
Synonyms:
4-(4-fluoro-5,6-dimethoxybenzo[b]thiophen- 2-yl)-4-oxobutanoic acid | US10730849, Example 14 | US10730849, Example 25
Type:
Small organic molecule
Emp. Form.:
C14H13FO5S
Mol. Mass.:
312.313
SMILES:
COc1cc2sc(cc2c(F)c1OC)C(=O)CCC(O)=O
Structure:
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