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Target
Plasma kallikrein
Ligand
BDBM454966
Substrate
n/a
Meas. Tech.
Inhibitory Activity of Exemplary Compounds against Plasma Kallikrein
EC50
<1.0±n/a nM
Citation
 Papaioannou, N; Fink, SJ; Miller, TA; Shipps, Jr., GW; Travins, JM; Ehmann, DE; Rae, A; Ellard, JM Inhibitors of plasma kallikrein and uses thereof US Patent  US10730874 Publication Date 8/4/2020 
Target
Name:
Plasma kallikrein
Synonyms:
Fletcher factor | KLK3 | KLKB1 | KLKB1_HUMAN | Kallikrein | Kininogenin | Plasma kallikrein heavy chain | Plasma kallikrein light chain | Plasma prekallikrein
Type:
Protein
Mol. Mass.:
71391.16
Organism:
Homo sapiens (Human)
Description:
P03952
Residue:
638
Sequence:
MILFKQATYFISLFATVSCGCLTQLYENAFFRGGDVASMYTPNAQYCQMRCTFHPRCLLFSFLPASSINDMEKRFGCFLKDSVTGTLPKVHRTGAVSGHSLKQCGHQISACHRDIYKGVDMRGVNFNVSKVSSVEECQKRCTSNIRCQFFSYATQTFHKAEYRNNCLLKYSPGGTPTAIKVLSNVESGFSLKPCALSEIGCHMNIFQHLAFSDVDVARVLTPDAFVCRTICTYHPNCLFFTFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKRTLPEPCHSKIYPGVDFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRIAYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
  
Inhibitor
Name:
BDBM454966
Synonyms:
US10730874, Compound I-5 | US11352356, Compound I-5
Type:
Small organic molecule
Emp. Form.:
C23H20BrN7O
Mol. Mass.:
490.355
SMILES:
Brc1ccn2cnc(CNC(=O)c3cnn(Cc4cn5cc(ccc5n4)C4CC4)c3)c2c1
Structure:
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