Reaction Details Report a problem with these data
Target
Retinoic acid receptor gamma
Ligand
BDBM458152
Substrate
n/a
Meas. Tech.
Transactivation assays
EC50
0.530±n/a nM
Citation
 Borthwick, AD; Mills, MT; Brown, JT; Corcoran, JP; De Castro Vasconcelos Goncalves, MB; Kalindjian, SB Bicycloheteroaryl-heteroaryl-benzoic acid compounds as retinoic acid receptor beta (RARβ) agonists US Patent  US10752616 Publication Date 8/25/2020 
Target
Name:
Retinoic acid receptor gamma
Synonyms:
NR1B3 | Nuclear receptor subfamily 1 group B member 3 | RAR-gamma | RARG | RARG_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoic acid receptor gamma | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50345.43
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1458016
Residue:
454
Sequence:
MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA
  
Inhibitor
Name:
BDBM458152
Synonyms:
US10752616, Code No. BHBA-010
Type:
Small organic molecule
Emp. Form.:
C21H18N2O4
Mol. Mass.:
362.3786
SMILES:
CC(C)c1ccc(C)c2oc(cc12)-c1nc(no1)-c1ccc(cc1)C(O)=O
Structure:
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