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Target
Serine/threonine-protein kinase 4
Ligand
BDBM461300
Substrate
n/a
Meas. Tech.
MST1/MST2 Biochemical LanthaScreen Eu Kinase Binding Assay
IC50
<100±n/a nM
Citation
 Petrassi, HM; Peram Surakattula, MM; Maedler, K; Ardestani, A; Roland, JT; Baguley, TD; Tremblay, MS; Shen, W; Schultz, PG; Chatterjee, AK Composition and methods for inhibiting mammalian sterile 20-like kinase 1 US Patent  US10774068 Publication Date 9/15/2020 
Target
Name:
Serine/threonine-protein kinase 4
Synonyms:
KRS2 | MST1 | STK4 | STK4_HUMAN | Serine/threonine-protein kinase 3/4 | Serine/threonine-protein kinase 4 (STK4) | Serine/threonine-protein kinase MST1
Type:
Enzyme
Mol. Mass.:
55611.40
Organism:
Homo sapiens (Human)
Description:
Q13043
Residue:
487
Sequence:
METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLKNSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKRRQQNF
  
Inhibitor
Name:
BDBM461300
Synonyms:
US10774068, Example 7 | US11427560, Example 7
Type:
Small organic molecule
Emp. Form.:
C30H30Cl2N6O3
Mol. Mass.:
593.504
SMILES:
CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4cccc(Cl)n4)c(Cl)c3)c2cc1NC(=O)CCCN(C)C
Structure:
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