Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 3 [397-806]
Ligand
BDBM350069
Substrate
n/a
IC50
6.40±n/a nM
Citation
 Andrews, SW; Blake, JF; Cook, A; Gunawardana, IW; Hunt, KW; Metcalf, AT; Moreno, D; Ren, L; Tang, TP 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases US Patent  US10766881 Publication Date 9/8/2020 
Target
Name:
Fibroblast growth factor receptor 3 [397-806]
Synonyms:
FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor 3 (FGFR-3) | Fibroblast growth factor receptor 3 (FGFR3) (R397-T806) | JTK4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45431.04
Organism:
Homo sapiens (Human)
Description:
P22607[397-806]
Residue:
410
Sequence:
RLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM350069
Synonyms:
US10208024, Example 68 | US10766881, Example 68
Type:
Small organic molecule
Emp. Form.:
C26H26Cl2N8O4
Mol. Mass.:
585.442
SMILES:
COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CC(=O)N2CCCCC2)c1 |(11.98,-.21,;10.65,-.98,;9.32,-.21,;9.32,1.33,;7.98,2.1,;7.98,3.64,;9.32,4.41,;6.65,1.33,;5.32,2.1,;6.65,-.21,;7.98,-.98,;7.98,-2.52,;5.32,-.98,;3.98,-.21,;2.65,-.98,;2.65,-2.52,;3.98,-3.29,;5.32,-2.52,;6.65,-3.29,;1.32,-.21,;-.02,-.98,;-1.35,-.21,;-1.35,1.33,;-.02,2.1,;1.32,1.33,;2.65,2.1,;-2.69,-.98,;-2.69,-2.52,;-4.15,-2.99,;-5.06,-1.75,;-6.6,-1.75,;-7.37,-3.08,;-6.6,-4.41,;-8.9,-3.08,;-9.67,-1.75,;-11.21,-1.75,;-11.98,-3.08,;-11.21,-4.41,;-9.67,-4.41,;-4.15,-.5,)|
Structure:
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