Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 3 [397-806]
Ligand
BDBM350073
Substrate
n/a
IC50
5.20±n/a nM
Citation
 Andrews, SW; Blake, JF; Cook, A; Gunawardana, IW; Hunt, KW; Metcalf, AT; Moreno, D; Ren, L; Tang, TP 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases US Patent  US10766881 Publication Date 9/8/2020 
Target
Name:
Fibroblast growth factor receptor 3 [397-806]
Synonyms:
FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor 3 (FGFR-3) | Fibroblast growth factor receptor 3 (FGFR3) (R397-T806) | JTK4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45431.04
Organism:
Homo sapiens (Human)
Description:
P22607[397-806]
Residue:
410
Sequence:
RLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM350073
Synonyms:
6-(3-amino-6-(1-(1- hydroxy-2- methylpropan-2-yl)-1H- pyrazol-4-yl)pyrazin-2- yl)-2-(2,6-dichloro-3,5- dimethoxyphenyl)pyridazin- 3(2H)-one | US10208024, Example 72 | US10766881, Example 72
Type:
Small organic molecule
Emp. Form.:
C23H23Cl2N7O4
Mol. Mass.:
532.379
SMILES:
COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C(C)(C)CO |(7.78,3.85,;6.44,3.08,;6.44,1.54,;7.78,.77,;7.78,-.77,;9.11,-1.54,;10.45,-.77,;6.44,-1.54,;6.44,-3.08,;5.11,-.77,;5.11,.77,;3.78,1.54,;3.78,-1.54,;2.44,-.77,;1.11,-1.54,;1.11,-3.08,;2.44,-3.85,;3.78,-3.08,;5.11,-3.85,;-.22,-.77,;-1.56,-1.54,;-2.89,-.77,;-2.89,.77,;-1.56,1.54,;-.22,.77,;1.11,1.54,;-4.23,-1.54,;-4.23,-3.08,;-5.69,-3.56,;-6.6,-2.31,;-5.69,-1.06,;-8.14,-2.31,;-8.91,-.98,;-7.37,-.98,;-8.91,-3.64,;-10.45,-3.64,)|
Structure:
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