Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 3 [397-806]
Ligand
BDBM350075
Substrate
n/a
IC50
6.10±n/a nM
Citation
 Andrews, SW; Blake, JF; Cook, A; Gunawardana, IW; Hunt, KW; Metcalf, AT; Moreno, D; Ren, L; Tang, TP 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases US Patent  US10766881 Publication Date 9/8/2020 
Target
Name:
Fibroblast growth factor receptor 3 [397-806]
Synonyms:
FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor 3 (FGFR-3) | Fibroblast growth factor receptor 3 (FGFR3) (R397-T806) | JTK4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45431.04
Organism:
Homo sapiens (Human)
Description:
P22607[397-806]
Residue:
410
Sequence:
RLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM350075
Synonyms:
6-(3-amino-6-(1- cyclopropyl-1H-pyrazol- 4-yl)pyrazin-2-yl)-2-(2,6- dichloro-3,5- dimethoxyphenyl)pyridazin- 3(2H)-one | US10208024, Example 74 | US10766881, Example 74
Type:
Small organic molecule
Emp. Form.:
C22H19Cl2N7O3
Mol. Mass.:
500.337
SMILES:
COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C1CC1 |(7.29,3.85,;5.96,3.08,;5.96,1.54,;7.29,.77,;7.29,-.77,;8.62,-1.54,;9.96,-.77,;5.96,-1.54,;5.96,-3.08,;4.62,-.77,;4.62,.77,;3.29,1.54,;3.29,-1.54,;1.95,-.77,;.62,-1.54,;.62,-3.08,;1.95,-3.85,;3.29,-3.08,;4.62,-3.85,;-.71,-.77,;-2.05,-1.54,;-3.38,-.77,;-3.38,.77,;-2.05,1.54,;-.71,.77,;.62,1.54,;-4.71,-1.54,;-4.71,-3.08,;-6.18,-3.56,;-7.08,-2.31,;-6.18,-1.06,;-8.62,-2.31,;-9.96,-1.54,;-9.96,-3.08,)|
Structure:
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