Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 3 [397-806]
Ligand
BDBM350076
Substrate
n/a
IC50
10.2±n/a nM
Citation
 Andrews, SW; Blake, JF; Cook, A; Gunawardana, IW; Hunt, KW; Metcalf, AT; Moreno, D; Ren, L; Tang, TP 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases US Patent  US10766881 Publication Date 9/8/2020 
Target
Name:
Fibroblast growth factor receptor 3 [397-806]
Synonyms:
FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor 3 (FGFR-3) | Fibroblast growth factor receptor 3 (FGFR3) (R397-T806) | JTK4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45431.04
Organism:
Homo sapiens (Human)
Description:
P22607[397-806]
Residue:
410
Sequence:
RLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM350076
Synonyms:
6-(3-amino-6-(1- (azetidin-3-yl)-1H- pyrazol-4-yl)pyrazin-2- yl)-2-(2,6-dichloro-3,5- dimethoxyphenyl)pyridazin- 3(2H)-one | US10208024, Example 75 | US10766881, Example 75
Type:
Small organic molecule
Emp. Form.:
C22H20Cl2N8O3
Mol. Mass.:
515.352
SMILES:
COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C1CNC1 |(7.71,3.85,;6.38,3.08,;6.38,1.54,;7.71,.77,;7.71,-.77,;9.05,-1.54,;10.38,-.77,;6.38,-1.54,;6.38,-3.08,;5.04,-.77,;5.04,.77,;3.71,1.54,;3.71,-1.54,;2.38,-.77,;1.04,-1.54,;1.04,-3.08,;2.38,-3.85,;3.71,-3.08,;5.04,-3.85,;-.29,-.77,;-1.62,-1.54,;-2.96,-.77,;-2.96,.77,;-1.62,1.54,;-.29,.77,;1.04,1.54,;-4.29,-1.54,;-4.29,-3.08,;-5.76,-3.56,;-6.66,-2.31,;-5.76,-1.06,;-8.2,-2.31,;-9.29,-1.22,;-10.38,-2.31,;-9.29,-3.4,)|
Structure:
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