Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 3 [397-806]
Ligand
BDBM350079
Substrate
n/a
IC50
6.90±n/a nM
Citation
 Andrews, SW; Blake, JF; Cook, A; Gunawardana, IW; Hunt, KW; Metcalf, AT; Moreno, D; Ren, L; Tang, TP 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases US Patent  US10766881 Publication Date 9/8/2020 
Target
Name:
Fibroblast growth factor receptor 3 [397-806]
Synonyms:
FGFR3 | FGFR3_HUMAN | Fibroblast growth factor receptor 3 (FGFR-3) | Fibroblast growth factor receptor 3 (FGFR3) (R397-T806) | JTK4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45431.04
Organism:
Homo sapiens (Human)
Description:
P22607[397-806]
Residue:
410
Sequence:
RLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSAPFEQYSPGGQDTPSSSSSGDDSVFAHDLLPPAPPSSGGSRT
  
Inhibitor
Name:
BDBM350079
Synonyms:
US10208024, Example 78 | US10766881, Example 78
Type:
Small organic molecule
Emp. Form.:
C26H28Cl2N8O4
Mol. Mass.:
587.458
SMILES:
COCCN1CC(C1)n1cc(cn1)-c1cnc(N)c(n1)-c1cc(C)c(=O)n(n1)-c1c(Cl)c(OC)cc(OC)c1Cl |(-12.69,-4.21,;-11.92,-2.87,;-10.38,-2.87,;-9.61,-1.54,;-8.07,-1.54,;-6.98,-.45,;-5.89,-1.54,;-6.98,-2.63,;-4.35,-1.54,;-3.45,-.29,;-1.98,-.77,;-1.98,-2.31,;-3.45,-2.79,;-.65,,;-.65,1.54,;.69,2.31,;2.02,1.54,;3.35,2.31,;2.02,,;.69,-.77,;3.35,-.77,;3.35,-2.31,;4.69,-3.08,;4.69,-4.62,;6.02,-2.31,;7.35,-3.08,;6.02,-.77,;4.69,,;7.35,,;8.69,-.77,;8.69,-2.31,;10.02,,;11.36,-.77,;12.69,,;10.02,1.54,;8.69,2.31,;8.69,3.85,;10.02,4.62,;7.35,1.54,;6.02,2.31,)|
Structure:
Search PDB for entries with ligand similarity: