Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM474710
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<1000±n/a nM
Citation
 Kotian, PL; Babu, YS; Zhang, W; Vogeti, L; Wu, M; Chintareddy, VR; Raman, K Benzopyrazole compounds and analogues thereof US Patent  US10849883 Publication Date 12/1/2020 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM474710
Synonyms:
US10849883, Compound 134a | US11559515, Compound 134a
Type:
Small organic molecule
Emp. Form.:
C33H34ClFN4O4
Mol. Mass.:
605.099
SMILES:
CC(C)N(CC(=O)NCc1cccc(Cl)c1F)C(=O)Cn1cc(C(C)=O)c2cc(ccc12)C(=O)NC(C)c1ccccc1
Structure:
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