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Target
ADP-ribosylation factor 6
Ligand
BDBM474970
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
1.10±n/a nM
Citation
 Ostanin, K; Shenderovich, M; Bajji, A; Cioffi, CL; Moss, N; Vankayalapati, H; Li, D Arf6 inhibitors and methods of synthesis and use thereof US Patent  US10849901 Publication Date 12/1/2020 
Target
Name:
ADP-ribosylation factor 6
Synonyms:
ARF6 | ARF6_HUMAN
Type:
Protein
Mol. Mass.:
20087.47
Organism:
Human
Description:
P62330
Residue:
175
Sequence:
MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAIILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEGLTWLTSNYKS
  
Inhibitor
Name:
BDBM474970
Synonyms:
US10849901, Compound 20
Type:
Small organic molecule
Emp. Form.:
C29H20N4O3
Mol. Mass.:
472.4941
SMILES:
[O-][N+](=O)c1ccc(cc1)-c1cc(=O)n2nc(Cc3ccccc3)c(-c3cccc4ccccc34)c2[nH]1 |(6.88,-4.22,;6.88,-2.68,;8.21,-1.91,;5.54,-1.91,;4.16,-2.65,;2.83,-1.88,;2.83,-.34,;4.16,.43,;5.5,-.34,;1.49,.43,;1.49,1.97,;.16,2.74,;.16,4.28,;-1.17,1.97,;-2.64,2.44,;-3.54,1.2,;-5.08,1.2,;-5.85,2.53,;-5.08,3.87,;-5.85,5.2,;-7.39,5.2,;-8.16,3.87,;-7.39,2.53,;-2.64,-.05,;-3.04,-1.53,;-4.52,-1.93,;-4.92,-3.42,;-3.83,-4.51,;-2.35,-4.11,;-1.26,-5.2,;.23,-4.8,;.63,-3.31,;-.46,-2.22,;-1.95,-2.62,;-1.17,.43,;.16,-.34,)|
Structure:
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