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Target
Bromodomain-containing protein 4 [349-460]
Ligand
BDBM205429
Substrate
n/a
Meas. Tech.
Alpha-assay
IC50
52120000±n/a nM
Citation
 Landau, SB; Kagey, MH Treatment of conditions associated with hyperinsulinaemia US Patent  US10925881 Publication Date 2/23/2021 
Target
Name:
Bromodomain-containing protein 4 [349-460]
Synonyms:
BRD4 | BRD4 bromodomain 2 | BRD4_HUMAN | Brd4-2 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13087.06
Organism:
Homo sapiens (Human)
Description:
O60885[349-460]
Residue:
112
Sequence:
KVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE
  
Inhibitor
Name:
BDBM205429
Synonyms:
(R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10925881, Name (R)-JQ1 | US11028051, Cmpd (+)-JQ1 | US11117865, Compound JQ1 | US11306105, Compound JQ1 | US11406645, Compound JQ1 | US11542273, Example (+)-JQ1 | US11890288, Compound (+)-JQ1 | US9320741, (R)-JQ1
Type:
Small organic molecule
Emp. Form.:
C23H25ClN4O2S
Mol. Mass.:
456.988
SMILES:
Cc1nnc2[C@@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |r,c:14|
Structure:
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