Reaction Details Report a problem with these data
Target
GTPase KRas [G12D,Q61H]
Ligand
BDBM485658
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
7500±n/a nM
Citation
 Hadari, YR; Carta, L; Schmertzler, M; Williams, TM; Reynolds, CH; Hutcheson, R Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease US Patent  US11000515 Publication Date 5/11/2021 
Target
Name:
GTPase KRas [G12D,Q61H]
Synonyms:
GTPase KRas (G12D, Q61H) | KRAS | KRAS2 | RASK2 | RASK_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21722.64
Organism:
Homo sapiens (Human)
Description:
P01116[G12D,Q61H]
Residue:
189
Sequence:
MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGHEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
  
Inhibitor
Name:
BDBM485658
Synonyms:
US10940139, Example 02647 | US11000515, Compound TABLE 7.198 | US11213515, TABLE 7.198 | US11541041, Compound Table 7.177
Type:
Small organic molecule
Emp. Form.:
C20H18N4O4S
Mol. Mass.:
410.446
SMILES:
CS(=O)(=O)c1cccc(c1)C(=O)N1CCCc2c(O)nc(nc12)-c1ccccn1
Structure:
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