Reaction Details Report a problem with these data
Target
GTPase KRas [G12D,Q61H]
Ligand
BDBM485665
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
20500±n/a nM
Citation
 Hadari, YR; Carta, L; Schmertzler, M; Williams, TM; Reynolds, CH; Hutcheson, R Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease US Patent  US11000515 Publication Date 5/11/2021 
Target
Name:
GTPase KRas [G12D,Q61H]
Synonyms:
GTPase KRas (G12D, Q61H) | KRAS | KRAS2 | RASK2 | RASK_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21722.64
Organism:
Homo sapiens (Human)
Description:
P01116[G12D,Q61H]
Residue:
189
Sequence:
MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGHEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
  
Inhibitor
Name:
BDBM485665
Synonyms:
US10940139, Example 02767 | US11000515, Compound TABLE 7.318 | US11213515, TABLE 7.318 | US11541041, Compound Table 7.297
Type:
Small organic molecule
Emp. Form.:
C23H20N4O4S
Mol. Mass.:
448.494
SMILES:
COc1ccccc1C1CN(CCO1)C(=O)c1csc2c(O)nc(nc12)-c1ccccn1
Structure:
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