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Target
Tyrosine-protein kinase Mer
Ligand
BDBM497232
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
<3±n/a nM
Citation
 Wang, X; Zheng, H; Zhao, J; Zhang, W; Frye, SV Alkyl pyrrolopyrimidine analogs and methods of making and using same US Patent  US11001586 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein kinase Mer
Synonyms:
MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer
Type:
PROTEIN
Mol. Mass.:
110234.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1498723
Residue:
999
Sequence:
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
  
Inhibitor
Name:
BDBM497232
Synonyms:
(1S,4R)-4-(5-(1- (methylsulfonyl)piperidin- 4-yl)-2-(((S)-pentan-2- yl)amino)-7H-pyrrolo[2,3- d]pyrimidin-7- yl)cyclohexan-1-ol | US11001586, Example 5
Type:
Small organic molecule
Emp. Form.:
C23H37N5O3S
Mol. Mass.:
463.637
SMILES:
CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)S(C)(=O)=O |r,wU:13.12,wD:3.3,16.16,(-7.1,-2.31,;-5.76,-1.54,;-4.43,-2.31,;-3.09,-1.54,;-3.09,,;-1.76,-2.31,;-.43,-1.54,;-.43,,;.91,.77,;2.24,,;3.7,.48,;4.61,-.77,;3.7,-2.02,;4.18,-3.48,;5.69,-3.8,;6.16,-5.27,;5.13,-6.41,;5.61,-7.87,;3.63,-6.09,;3.15,-4.63,;2.24,-1.54,;.91,-2.31,;4.18,1.94,;5.69,2.26,;6.16,3.73,;5.13,4.87,;3.63,4.55,;3.15,3.09,;5.61,6.33,;7.1,5.94,;5.61,7.87,;4.12,6.73,)|
Structure:
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