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Target
Tyrosine-protein kinase Mer
Ligand
BDBM497269
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
<3±n/a nM
Citation
 Wang, X; Zheng, H; Zhao, J; Zhang, W; Frye, SV Alkyl pyrrolopyrimidine analogs and methods of making and using same US Patent  US11001586 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein kinase Mer
Synonyms:
MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer
Type:
PROTEIN
Mol. Mass.:
110234.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1498723
Residue:
999
Sequence:
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
  
Inhibitor
Name:
BDBM497269
Synonyms:
(1-(2-fluoroethyl)piperidin- 4-yl)(4-(7-((1R,4S)-4- hydroxycyclohexyl)-2- (((S)-pentan-2-yl)amino)- 7H-pyrrolo[2,3- d]pyrimidin-5-yl)piperidin- 1-yl)methanone | US11001586, Example 36
Type:
Small organic molecule
Emp. Form.:
C30H47FN6O2
Mol. Mass.:
542.7316
SMILES:
CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC1)C(=O)C1CCN(CCF)CC1 |r,wU:13.12,wD:3.3,16.16,(-10.62,-2.22,;-9.28,-1.45,;-7.95,-2.22,;-6.61,-1.45,;-6.61,.09,;-5.28,-2.22,;-3.95,-1.45,;-3.95,.09,;-2.61,.86,;-1.28,.09,;.19,.57,;1.09,-.68,;.19,-1.92,;.66,-3.39,;2.17,-3.71,;2.64,-5.17,;1.61,-6.32,;2.09,-7.78,;.11,-6,;-.37,-4.53,;-1.28,-1.45,;-2.61,-2.22,;.66,2.03,;2.17,2.35,;2.64,3.82,;1.61,4.96,;.11,4.64,;-.37,3.18,;2.09,6.43,;1.35,7.78,;3.58,6.03,;3.97,4.54,;5.46,4.14,;6.55,5.23,;8.04,4.83,;9.13,5.92,;10.62,5.52,;6.15,6.72,;4.67,7.12,)|
Structure:
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