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Target
Tyrosine-protein kinase Mer
Ligand
BDBM497313
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
750±n/a nM
Citation
 Wang, X; Zheng, H; Zhao, J; Zhang, W; Frye, SV Alkyl pyrrolopyrimidine analogs and methods of making and using same US Patent  US11001586 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein kinase Mer
Synonyms:
MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer
Type:
PROTEIN
Mol. Mass.:
110234.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1498723
Residue:
999
Sequence:
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
  
Inhibitor
Name:
BDBM497313
Synonyms:
(1S,4r)-4-(5-(1-((2,6- dimethylpyridin-4- yl)methyl)piperidin-4-yl)-2- (((S)-1-phenylethyl)amino)- 7H-pyrrolo[2,3- d]pyrimidin-7- yl)cyclohexan-1-ol | US11001586, Example 91
Type:
Small organic molecule
Emp. Form.:
C33H42N6O
Mol. Mass.:
538.7262
SMILES:
C[C@H](Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(Cc2cc(C)nc(C)c2)CC1)c1ccccc1 |r,wU:13.13,1.0,wD:10.9,(5.86,-1.39,;5.86,-2.93,;4.53,-3.7,;3.19,-2.93,;3.19,-1.39,;1.86,-.62,;.53,-1.39,;-.94,-.91,;-1.84,-2.16,;-.94,-3.4,;-1.41,-4.87,;-2.92,-5.19,;-3.4,-6.65,;-2.37,-7.8,;-2.84,-9.26,;-.86,-7.48,;-.38,-6.01,;.53,-2.93,;1.86,-3.7,;-1.41,.55,;-2.92,.87,;-3.4,2.34,;-2.37,3.48,;-2.84,4.95,;-1.81,6.09,;-.31,5.77,;.72,6.92,;2.23,6.6,;.25,8.38,;-1.26,8.7,;-1.73,10.17,;-2.29,7.56,;-.86,3.16,;-.38,1.7,;7.19,-3.7,;8.53,-2.93,;9.86,-3.7,;9.86,-5.24,;8.53,-6.01,;7.19,-5.24,)|
Structure:
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