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Target
Tyrosine-protein kinase receptor TYRO3
Ligand
BDBM497323
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
<50±n/a nM
Citation
 Wang, X; Zheng, H; Zhao, J; Zhang, W; Frye, SV Alkyl pyrrolopyrimidine analogs and methods of making and using same US Patent  US11001586 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein kinase receptor TYRO3
Synonyms:
BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY
Type:
Protein
Mol. Mass.:
96894.13
Organism:
Homo sapiens (Human)
Description:
Q06418
Residue:
890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
  
Inhibitor
Name:
BDBM497323
Synonyms:
(2,6-dimethylpyridin-4- yl)(4-(7-((1r,4r)-4- hydroxycyclohexyl)-2- ((4,4,4- trifluorobutyl)amino)-7H- pyrrolo[2,3-d]pyrimidin-5- yl)piperidin-1- yl)methanone | US11001586, Example 101
Type:
Small organic molecule
Emp. Form.:
C29H37F3N6O2
Mol. Mass.:
558.6383
SMILES:
Cc1cc(cc(C)n1)C(=O)N1CCC(CC1)c1cn([C@H]2CC[C@H](O)CC2)c2nc(NCCCC(F)(F)F)ncc12 |r,wU:19.20,wD:22.24,(8.45,8.89,;7.97,7.42,;6.46,7.1,;5.99,5.64,;7.02,4.5,;8.53,4.82,;9.56,3.67,;9,6.28,;4.48,5.32,;3.45,6.46,;4.01,3.86,;5.04,2.71,;4.56,1.25,;3.05,.93,;2.02,2.07,;2.5,3.53,;2.58,-.54,;3.48,-1.78,;2.58,-3.03,;3.05,-4.5,;4.56,-4.82,;5.04,-6.28,;4.01,-7.42,;4.48,-8.89,;2.5,-7.1,;2.02,-5.64,;1.11,-2.55,;-.22,-3.32,;-1.55,-2.55,;-2.89,-3.32,;-4.22,-2.55,;-5.55,-3.32,;-6.89,-2.55,;-8.22,-3.32,;-9.56,-2.55,;-8.22,-4.86,;-9.56,-4.09,;-1.55,-1.01,;-.22,-.24,;1.11,-1.01,)|
Structure:
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