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Target
Tyrosine-protein kinase BTK
Ligand
BDBM499881
Substrate
n/a
Meas. Tech.
Mobility Shift Assay (MSA) Type B
IC50
1.20±n/a nM
Citation
 Bates, C; Eathiraj, S; Inagaki, H; Lapierre, J; Momose, T; Nakayama, K; Odagiri, T; Ota, M; Ota, Y; Shibata, Y; Tandon, M; Tsunemi, T Amino-pyrrolopyrimidinone compounds and methods of use thereof US Patent  US11020398 Publication Date 6/1/2021 
Target
Name:
Tyrosine-protein kinase BTK
Synonyms:
AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:
Enzyme
Mol. Mass.:
76289.95
Organism:
Homo sapiens (Human)
Description:
Q06187
Residue:
659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
  
Inhibitor
Name:
BDBM499881
Synonyms:
(S)-N-(cis-4-((5-(2-chloro-4- phenoxybenzoyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl)amino)cyclohexyl)-2- hydroxypropanamide | US11020398, Compound I-193
Type:
Small organic molecule
Emp. Form.:
C28H28ClN5O4
Mol. Mass.:
534.006
SMILES:
C[C@H](O)C(=O)N[C@H]1CC[C@H](CC1)Nc1ncnc2[nH]cc(C(=O)c3ccc(Oc4ccccc4)cc3Cl)c12 |r,wU:9.12,6.5,1.1,(-9.05,4.07,;-9.05,2.53,;-10.38,1.76,;-7.72,1.76,;-7.72,.22,;-6.38,2.53,;-5.05,1.76,;-3.72,2.53,;-2.38,1.76,;-2.38,.22,;-3.72,-.55,;-5.05,.22,;-1.05,-.55,;-1.05,-2.09,;-2.38,-2.86,;-2.38,-4.4,;-1.05,-5.17,;.29,-4.4,;1.75,-4.87,;2.66,-3.63,;1.75,-2.38,;2.15,-.89,;1.06,.2,;3.64,-.49,;4.03,.99,;5.52,1.39,;6.61,.3,;8.1,.7,;8.5,2.19,;9.99,2.59,;10.38,4.08,;9.29,5.17,;7.81,4.77,;7.41,3.28,;6.21,-1.18,;4.73,-1.58,;4.33,-3.07,;.29,-2.86,)|
Structure:
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